TMCO4

Across TCGA cell cohorts, TMCO4 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMCO4-associated genes across cancer lineages are USP29, OR6C2, and DNAAF6. Each is linked with TMCO4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMCO4-to-partner and partner-to-TMCO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP29 grouped by TMCO4-low versus TMCO4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO4→partner) and Y-score (partner→TMCO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	USP29 →	+0.009	+4.415	<.001	.007	3	3
URINARY_TRACT	OR6C2 →	+0.178	+4.584	<.001	.002	3	2
LUNG_NSCLC_LUAD	DNAAF6 →	+0.030	+3.693	.005	.009	3	2
URINARY_TRACT	SMIM23 →	+0.010	+4.087	<.001	.009	3	1
LARGE_INTESTINE	CRISP2 →	+0.025	+4.467	<.001	.004	3	1
LARGE_INTESTINE	MCHR2 →	+0.022	+4.684	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

USP29 by TMCO4 expression — LARGE_INTESTINE

Explore this box plot interactively →