TMCO1

Across TCGA pan-cancer cohorts, TMCO1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMCO1 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TMCO1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TMCO1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where TMCO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.476	0.872	<.001	49	view →
HNSC	OS	Median	III,IV	0.797	0.564	.005	41	view →
LUAD	DFS	Median	All	0.516	0.738	.010	17	view →
LSCC	OS	Median	All	1.000	0.936	.009	8	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMCO1–CCRCC (OS)

Open the CCRCC breakdown →