TMCO1

Across TCGA patient cohorts, TMCO1 mutation is significantly associated with the RNA expression of many other genes, with 216 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMCO1-associated genes across cancer lineages are SALL4P5, RPS3AP17, and PMM2P1. Each is linked with TMCO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMCO1-to-partner and partner-to-TMCO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SALL4P5 grouped by TMCO1-low versus TMCO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO1→partner) and Y-score (partner→TMCO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SALL4P5 →	+0.070	+2.550	<.001	.006	3	2
SKCM	RPS3AP17 →	+0.052	+5.199	<.001	.003	3	2
HNSC	PMM2P1 →	+0.079	+5.069	<.001	.008	3	1
UCEC	HMOX1 →	+0.897	+3.332	.005	.005	3	1
UCEC	TIMM44 →	+0.445	+3.354	.008	.005	3	1
UCEC	RAB34 →	+0.610	+3.218	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 216 associations by consensus.

SALL4P5 by TMCO1 expression — UCEC

Explore this box plot interactively →