TMCC1

Across TCGA cell cohorts, TMCC1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMCC1-associated genes across cancer lineages are OR9A2, VN1R2, and OR14A16. Each is linked with TMCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMCC1-to-partner and partner-to-TMCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9A2 grouped by TMCC1-low versus TMCC1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCC1→partner) and Y-score (partner→TMCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR9A2 →	+0.022	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	VN1R2 →	+0.006	+5.643	.003	.002	3	1
BLOOD_Lymphoma	OR14A16 →	+0.023	+5.643	<.001	.002	3	1
LARGE_INTESTINE	PF4V1 →	+0.297	+3.793	<.001	.007	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	REG1B →	+2.507	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR9A2 by TMCC1 expression — BLOOD_Lymphoma

Explore this box plot interactively →