TMC6

Across TCGA cell cohorts, TMC6 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMC6-associated genes across cancer lineages are OR10K1, ADIG, and OR4F15. Each is linked with TMC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMC6-to-partner and partner-to-TMC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10K1 grouped by TMC6-low versus TMC6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC6→partner) and Y-score (partner→TMC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10K1 →	+0.485	+3.556	<.001	.001	3	2
LUNG_SCLC	ADIG →	+0.065	+5.029	<.001	.006	3	2
LUNG_SCLC	OR4F15 →	+0.029	+5.029	<.001	.006	3	2
BLOOD_Lymphoma	OR11H1 →	+0.027	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	ASB15 →	+0.777	+3.843	<.001	.007	3	1
BLOOD_Lymphoma	KIAA2012 →	+0.020	+3.843	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

OR10K1 by TMC6 expression — BLOOD_Leukemia

Explore this box plot interactively →