TMC4

Across TCGA patient cohorts, TMC4 mutation is significantly associated with the RNA expression of many other genes, with 2,680 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC4-associated genes across cancer lineages are RNA5SP412, NF1P10, and RN7SL538P. Each is linked with TMC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMC4-to-partner and partner-to-TMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by TMC4-low versus TMC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC4→partner) and Y-score (partner→TMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.579	+2.028	<.001	<.001	3	3
CESC	NF1P10 →	+0.114	+5.154	<.001	<.001	3	3
LIHC	RN7SL538P →	+0.151	+5.878	<.001	.002	3	3
UCEC	THAP9 →	+0.285	+1.880	.003	.004	3	3
LUAD	MIR4779 →	+0.314	+4.285	.002	.003	3	3
COAD	H2AC18 →	+0.101	+2.830	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,680 associations by consensus.

RNA5SP412 by TMC4 expression — UCEC

Explore this box plot interactively →