TMC4

Across TCGA patient cohorts, TMC4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC4-associated genes across cancer lineages are RAD51, Cyclin-D1, and 14-3-3_beta. Each is linked with TMC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMC4-to-partner and partner-to-TMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by TMC4-low versus TMC4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC4→partner) and Y-score (partner→TMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RAD51 →	+0.262	+2.824	.035	.034	3	1
BLCA	Cyclin-D1 →	+0.274	+3.000	.012	.036	3	1
UCEC	14-3-3_beta →	-0.069	-1.673	.030	.040	3	1
UCEC	ERK2 →	+0.122	+1.415	.048	.043	3	1
UCEC	JNK2 →	+0.170	+1.901	.007	.028	3	1
UCEC	MEK1 →	+0.368	+2.700	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

RAD51 by TMC4 expression — BLCA

Explore this box plot interactively →