TMC4

Across TCGA cell cohorts, TMC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,741 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMC4-associated GO terms across cancer lineages are Sensory perception of salty taste, Regulation of inner ear receptor cell differentiation, and tRNA wobble uridine modification. Each is linked with TMC4 in more than 12 cancer types. Because this analysis shows association rather than direction, both TMC4-to-partner and partner-to-TMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sensory perception of salty taste grouped by TMC4-low versus TMC4-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC4→partner) and Y-score (partner→TMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Sensory perception of salty taste →	+1.688	+2.993	<.001	.001	3	13
URINARY_TRACT	Regulation of inner ear receptor cell differentiation →	+1.303	+3.771	.001	<.001	3	13
LUNG_SCLC	tRNA wobble uridine modification →	-0.110	-2.249	<.001	<.001	3	13
STOMACH	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.182	+2.633	<.001	<.001	3	13
STOMACH	Cytotoxic T cell degranulation →	+0.268	+2.678	<.001	<.001	3	13
URINARY_TRACT	Regulation of mechanoreceptor differentiation →	+1.303	+3.771	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,741 associations by consensus.

Sensory perception of salty taste by TMC4 expression — OESOPHAGUS

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