TMC4

Across TCGA cell cohorts, TMC4 mutation is significantly associated with the mutation status of many other genes, with 2,724 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMC4-associated genes across cancer lineages are LETM1, EPHA10, and ATP13A5. Each is linked with TMC4 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMC4-to-partner and partner-to-TMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LETM1 grouped by TMC4-low versus TMC4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC4→partner) and Y-score (partner→TMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LETM1 →	+4.772	+5.339	.004	.004	1	5
SOFT_TISSUE	EPHA10 →	+5.502	+5.502	.003	.003	1	4
LUNG_NSCLC_LUAD	ATP13A5 →	+4.187	+5.000	.008	.008	1	4
LUNG_NSCLC_LUAD	KIF1C →	+5.772	+5.772	.002	.002	1	4
BLOOD_Leukemia	SYT3 →	+2.638	+2.341	.009	.009	1	4
OVARY	SRCAP →	+2.288	+2.639	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,724 associations by consensus.

LETM1 by TMC4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →