TMC3-AS1

Across TCGA pan-cancer cohorts, TMC3-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TMC3-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TMC3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMC3-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and READ show a favorable association.

KIRP, PAAD, and READ are the cancer types where TMC3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.592	0.817	.001	96	view →
PAAD	OS	Median	All	0.702	0.442	<.001	63	view →
READ	DFS	Median	All	0.704	0.412	.003	48	view →
LUSC	DFS	Quartile	II,III,IV	0.447	0.711	<.001	40	view →
ACC	OS	Median	III,IV	0.538	0.918	<.001	37	view →
UVM	DFS	Quartile	II,III,IV	0.833	0.494	.021	26	view →
BRCA	OS	Tertile	III,IV	0.897	0.754	.011	21	view →
MESO	OS	Median	II,III,IV	0.685	0.360	.011	21	view →
SKCM	OS	Median	IV	0.394	0.771	.005	15	view →
LUAD	DFS	Quartile	All	0.533	0.229	.006	14	view →
ESCA	DFS	Tertile	IV	0.216	0.692	.024	12	view →
HNSC	OS	Tertile	All	0.648	0.855	.003	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TMC3-AS1–KIRP (OS)

Open the KIRP breakdown →