TMC3-AS1

Across TCGA pan-cancer cohorts, TMC3-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TMC3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TMC3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types TMC3-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, COAD, and KIRC are the cancer types where TMC3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMC3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.472	<.001	10	view →
COAD	Male	II,III,IV	+0.740	<.001	8	view →
KIRC	Male	II,III,IV	+0.188	<.001	8	view →
HNSC	All	All	+0.217	.002	7	view →
LUAD	Male	All	+0.430	<.001	5	view →
KICH	All	All	−0.237	.001	5	view →
BRCA	All	All	+0.207	.007	4	view →
CHOL	All	All	−0.462	.017	2	view →
PRAD	All	All	+0.421	<.001	2	view →
LIHC	Female	All	−0.395	.004	1	view →
STAD	All	II,III,IV	+0.364	.037	1	view →
LIHC	Male	All	+0.285	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TMC3-AS1–THCA

Open the THCA breakdown →