TMBIM7P

Across TCGA pan-cancer cohorts, TMBIM7P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TMBIM7P’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TMBIM7P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMBIM7P is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.

LUSC, LUAD, and KICH are the cancer types where TMBIM7P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMBIM7P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+0.134	<.001	5	view →
LUAD	All	All	+0.088	<.001	5	view →
KICH	All	All	+0.372	.001	4	view →
PAAD	Male	All	+0.135	.032	2	view →
KIRP	Female	All	−0.034	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TMBIM7P–LUSC

Open the LUSC breakdown →