TMBIM4

Across TCGA cell cohorts, TMBIM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,558 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMBIM4-associated GO terms across cancer lineages are rRNA pseudouridine synthesis, Protein deglycosylation, and IMP biosynthetic process. Each is linked with TMBIM4 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMBIM4-to-partner and partner-to-TMBIM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA pseudouridine synthesis grouped by TMBIM4-low versus TMBIM4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMBIM4→partner) and Y-score (partner→TMBIM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	rRNA pseudouridine synthesis →	-0.124	-0.819	<.001	<.001	3	12
LUNG_SCLC	Protein deglycosylation →	+0.111	+1.352	<.001	<.001	3	12
BONE	IMP biosynthetic process →	-0.155	-0.788	<.001	<.001	3	12
BONE	rRNA metabolic process →	-0.138	-0.917	<.001	<.001	3	11
BONE	Ribosome biogenesis →	-0.128	-0.927	.001	<.001	3	11
LIVER	tRNA wobble position uridine thiolation →	-0.077	-0.641	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,558 associations by consensus.

rRNA pseudouridine synthesis by TMBIM4 expression — BONE

Explore this box plot interactively →