TMBIM4

Across TCGA pan-cancer cohorts, TMBIM4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TMBIM4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TMBIM4 RNA is repressed in tumor relative to normal tissue. In most cancer types TMBIM4 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, KICH, and UCEC are the cancer types where TMBIM4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMBIM4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	III,IV	−1.664	<.001	8	view →
KICH	Female	All	−1.049	<.001	8	view →
UCEC	All	II,III,IV	−0.931	<.001	8	view →
LIHC	Male	All	+0.639	<.001	8	view →
COAD	Female	All	−0.950	<.001	6	view →
LUAD	All	III,IV	−0.591	<.001	6	view →
BRCA	All	III,IV	+0.436	.007	5	view →
READ	All	All	−0.708	.006	3	view →
CHOL	All	All	+0.665	.007	2	view →
KIRP	All	All	−0.360	.008	2	view →
HNSC	Male	II,III,IV	−0.287	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TMBIM4–LUSC

Open the LUSC breakdown →