TMBIM4

Across TCGA cell cohorts, TMBIM4 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TMBIM4-associated genes across cancer lineages are OR1L6, OR11A1, and OR5V1. Each is linked with TMBIM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMBIM4-to-partner and partner-to-TMBIM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by TMBIM4-low versus TMBIM4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMBIM4→partner) and Y-score (partner→TMBIM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR1L6 →	+0.020	+5.807	<.001	.001	3	1
OVARY	OR11A1 →	+0.006	+5.196	<.001	.005	3	1
OVARY	OR5V1 →	+0.013	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR1L6 by TMBIM4 expression — OVARY

Explore this box plot interactively →