TMBIM1

Across TCGA pan-cancer cohorts, TMBIM1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TMBIM1 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TMBIM1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TMBIM1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where TMBIM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.468	0.675	.017	25	view →
HNSC	DFS	Quartile	All	0.825	0.573	.019	13	view →
CCRCC	DFS	Quartile	All	0.640	0.958	<.001	11	view →
LSCC	OS	Median	II,III,IV	0.526	0.840	.025	5	view →
GBM	DFS	Quartile	All	0.259	0.448	.017	4	view →
LUAD	DFS	Median	III,IV	0.732	1.000	.038	3	view →
UCEC	OS	Median	All	0.989	0.899	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TMBIM1–PDAC (OS)

Open the PDAC breakdown →