TMBIM1

Across TCGA pan-cancer cohorts, TMBIM1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMBIM1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where TMBIM1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMBIM1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

LIHC, KICH, and BRCA are the cancer types where TMBIM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMBIM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	III,IV	+1.349	<.001	9	view →
KICH	Male	All	−0.885	<.001	9	view →
BRCA	All	III,IV	−1.035	<.001	8	view →
THCA	All	All	−0.270	.001	8	view →
HNSC	Female	III,IV	+0.835	.003	7	view →
UCEC	All	All	−1.224	<.001	6	view →
LUAD	Female	All	−0.502	<.001	6	view →
CHOL	All	All	+1.593	<.001	5	view →
COAD	All	All	−0.317	.001	5	view →
LUSC	All	II,III,IV	−0.492	.001	4	view →
READ	All	All	−0.520	.002	3	view →
STAD	Male	III,IV	+0.748	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMBIM1–LIHC

Open the LIHC breakdown →