TMBIM1

Across TCGA patient cohorts, TMBIM1 mutation is significantly associated with the RNA expression of many other genes, with 1,186 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMBIM1-associated genes across cancer lineages are FRG1BP, CHEK1, and VPS26B. Each is linked with TMBIM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMBIM1-to-partner and partner-to-TMBIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRG1BP grouped by TMBIM1-low versus TMBIM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMBIM1→partner) and Y-score (partner→TMBIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FRG1BP →	+0.833	+2.700	.008	.006	3	1
UCEC	CHEK1 →	+0.690	+2.721	.003	.003	3	1
UCEC	VPS26B →	+0.422	+3.491	.007	.002	3	1
UCEC	GUF1 →	+0.490	+3.483	.003	.002	3	1
UCEC	SKA1 →	+0.636	+2.711	.009	.003	3	1
UCEC	PDZD9 →	+0.162	+2.775	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,186 associations by consensus.

FRG1BP by TMBIM1 expression — UCEC

Explore this box plot interactively →