TMBIM1

Across TCGA patient cohorts, TMBIM1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMBIM1-associated genes across cancer lineages are FoxM1, JNK2, and Ku80. Each is linked with TMBIM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMBIM1-to-partner and partner-to-TMBIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TMBIM1-low versus TMBIM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMBIM1→partner) and Y-score (partner→TMBIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.295	+3.009	.014	.019	3	1
UCEC	JNK2 →	+0.261	+2.817	.004	.036	3	1
UCEC	Ku80 →	+0.250	+1.887	.023	.031	3	1
UCEC	Notch1 →	+0.198	+3.013	.002	.018	3	1
UCEC	PRAS40_pT246 →	+0.249	+2.598	.001	.006	3	1
UCEC	Rab11 →	-0.147	-2.999	.029	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FoxM1 by TMBIM1 expression — UCEC

Explore this box plot interactively →