TMBIM1

Across TCGA cell cohorts, TMBIM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,515 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMBIM1-associated GO terms across cancer lineages are Actin filament capping, Regulation of proteolysis, and Negative regulation of actin filament depolymerization. Each is linked with TMBIM1 in more than 13 cancer types. Because this analysis shows association rather than direction, both TMBIM1-to-partner and partner-to-TMBIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament capping grouped by TMBIM1-low versus TMBIM1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMBIM1→partner) and Y-score (partner→TMBIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Actin filament capping →	+0.279	+1.835	<.001	<.001	3	14
BONE	Regulation of proteolysis →	+0.138	+1.893	.001	<.001	3	14
BONE	Negative regulation of actin filament depolymerization →	+0.260	+1.883	<.001	<.001	3	14
BLOOD_Lymphoma	Intracellular receptor signaling pathway →	+0.049	+1.651	<.001	<.001	3	14
BONE	Plasma membrane organization →	+0.154	+1.469	<.001	.001	3	14
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.064	+1.579	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,515 associations by consensus.

Actin filament capping by TMBIM1 expression — BONE

Explore this box plot interactively →