TM9SF4

Across TCGA pan-cancer cohorts, TM9SF4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TM9SF4 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TM9SF4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TM9SF4 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where TM9SF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	0.462	0.938	<.001	59	view →
HNSC	DFS	Quartile	All	0.930	0.746	.018	7	view →
LUAD	DFS	Quartile	II,III,IV	0.291	0.783	.010	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TM9SF4–CCRCC (OS)

Open the CCRCC breakdown →