TM9SF4

Across TCGA pan-cancer cohorts, TM9SF4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TM9SF4’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where TM9SF4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TM9SF4 is over-expressed in tumor.

BLCA, HNSC, and LUAD are the cancer types where TM9SF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TM9SF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+0.845	<.001	11	view →
HNSC	All	III,IV	+0.787	<.001	11	view →
LUAD	All	III,IV	+0.724	<.001	11	view →
KIRC	Female	III,IV	+0.435	<.001	11	view →
STAD	Male	II,III,IV	+1.164	<.001	10	view →
COAD	Male	II,III,IV	+1.011	<.001	10	view →
LIHC	Female	II,III,IV	+1.227	<.001	8	view →
LUSC	Male	II,III,IV	+1.046	<.001	8	view →
KIRP	All	II,III,IV	+0.811	<.001	7	view →
BRCA	All	III,IV	+0.720	<.001	6	view →
CHOL	Male	All	+1.826	<.001	5	view →
ESCA	Female	All	+0.973	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TM9SF4–BLCA

Open the BLCA breakdown →