TM9SF4

Across TCGA patient cohorts, TM9SF4 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM9SF4-associated genes across cancer lineages are EGFR_pY1068, S6_pS240_S244, and 14-3-3_beta. Each is linked with TM9SF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM9SF4-to-partner and partner-to-TM9SF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TM9SF4-low versus TM9SF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM9SF4→partner) and Y-score (partner→TM9SF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.193	-1.765	.040	.014	3	2
UCEC	S6_pS240_S244 →	+0.316	+1.415	.038	.046	3	2
UCEC	14-3-3_beta →	-0.084	-3.295	.025	.009	3	1
UCEC	eIF4G →	+0.288	+2.584	.013	.010	3	1
UCEC	A-Raf_pS299 →	-0.124	-2.459	.005	.019	3	1
UCEC	INPP4B →	-0.393	-3.807	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by TM9SF4 expression — UCEC

Explore this box plot interactively →