TM9SF4

Across TCGA cell cohorts, TM9SF4 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TM9SF4-associated genes across cancer lineages are NUPR2, IQCF6, and FOXB2. Each is linked with TM9SF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM9SF4-to-partner and partner-to-TM9SF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUPR2 grouped by TM9SF4-low versus TM9SF4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM9SF4→partner) and Y-score (partner→TM9SF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NUPR2 →	+0.395	+4.273	<.001	.006	3	1
LARGE_INTESTINE	IQCF6 →	+0.322	+4.467	<.001	.004	3	1
SKIN	FOXB2 →	+0.022	+5.415	<.001	.004	3	1
SKIN	OR2J2 →	+0.013	+4.977	<.001	.007	3	1
SKIN	OR8B4 →	+0.021	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	LRRC74A →	+0.012	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

NUPR2 by TM9SF4 expression — LARGE_INTESTINE

Explore this box plot interactively →