TM9SF2

Across TCGA patient cohorts, TM9SF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,161 significant associations in total. THYM shows the largest number of these associations.

The most reproducible TM9SF2-associated GO terms across cancer lineages are COPII-coated vesicle cargo loading, Retrograde transport, vesicle recycling within Golgi, and Establishment of mitotic sister chromatid cohesion. Each is linked with TM9SF2 in more than 30 cancer types. Because this analysis shows association rather than direction, both TM9SF2-to-partner and partner-to-TM9SF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPII-coated vesicle cargo loading grouped by TM9SF2-low versus TM9SF2-high in UCS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TM9SF2→partner) and Y-score (partner→TM9SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	COPII-coated vesicle cargo loading →	+0.132	+1.004	<.001	<.001	3	31
SCLC	Retrograde transport, vesicle recycling within Golgi →	+0.126	+0.598	<.001	<.001	3	31
DLBC	Establishment of mitotic sister chromatid cohesion →	+0.092	+0.772	<.001	<.001	3	30
SCLC	Regulation of translation initiation in response to endoplasmic reticulum stress →	+0.136	+0.539	<.001	.003	3	30
THYM	Regulation of translation in response to stress →	+0.067	+0.979	<.001	<.001	3	30
THYM	Regulation of vacuole organization →	+0.060	+0.985	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,161 associations by consensus.

COPII-coated vesicle cargo loading by TM9SF2 expression — UCS

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