TM9SF2

Across TCGA patient cohorts, TM9SF2 mutation is significantly associated with the RNA expression of many other genes, with 1,916 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM9SF2-associated genes across cancer lineages are NUDT4P2, VTRNA2-2P, and TGM7. Each is linked with TM9SF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM9SF2-to-partner and partner-to-TM9SF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUDT4P2 grouped by TM9SF2-low versus TM9SF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM9SF2→partner) and Y-score (partner→TM9SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUDT4P2 →	+0.022	+2.106	.003	.007	3	2
CESC	VTRNA2-2P →	+0.445	+4.601	<.001	.004	3	2
UCEC	TGM7 →	+0.945	+2.080	<.001	<.001	3	2
LUAD	MIR1302-5 →	+0.256	+5.044	.003	.009	3	2
LUAD	RPS6P4 →	+0.097	+5.279	<.001	.006	3	2
COAD	SNRPCP20 →	+0.492	+3.831	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,916 associations by consensus.

NUDT4P2 by TM9SF2 expression — UCEC

Explore this box plot interactively →