TM9SF2

Across TCGA patient cohorts, TM9SF2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM9SF2-associated genes across cancer lineages are VHL, eIF4E, and A-Raf_pS299. Each is linked with TM9SF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM9SF2-to-partner and partner-to-TM9SF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by TM9SF2-low versus TM9SF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM9SF2→partner) and Y-score (partner→TM9SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.763	-2.459	.001	.018	3	2
UCEC	eIF4E →	+0.168	+3.183	.027	.009	3	1
UCEC	A-Raf_pS299 →	-0.136	-2.115	.001	.017	3	1
UCEC	ERK2 →	+0.160	+2.000	.020	.030	3	1
UCEC	JNK2 →	+0.181	+2.009	.011	.017	3	1
UCEC	Ku80 →	+0.216	+1.939	.011	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

VHL by TM9SF2 expression — UCEC

Explore this box plot interactively →