TM9SF2

Across TCGA cell cohorts, TM9SF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,401 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TM9SF2-associated GO terms across cancer lineages are Regulation of translation initiation in response to endoplasmic reticulum stress, Regulation of heparan sulfate proteoglycan biosynthetic process, and Regulation of protein O-linked glycosylation. Each is linked with TM9SF2 in more than 16 cancer types. Because this analysis shows association rather than direction, both TM9SF2-to-partner and partner-to-TM9SF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translation initiation in response to endoplasmic reticulum stress grouped by TM9SF2-low versus TM9SF2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TM9SF2→partner) and Y-score (partner→TM9SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of translation initiation in response to endoplasmic reticulum stress →	+0.179	+0.888	<.001	.002	3	17
BLOOD_Leukemia	Regulation of heparan sulfate proteoglycan biosynthetic process →	+0.136	+0.711	<.001	.001	3	15
BLOOD_Leukemia	Regulation of protein O-linked glycosylation →	+0.136	+0.711	<.001	.001	3	15
SOFT_TISSUE	Protein deglycosylation →	+0.119	+1.030	<.001	<.001	3	15
PANCREAS	Endoplasmic reticulum mannose trimming →	+0.123	+1.016	<.001	<.001	3	14
BONE	Positive regulation of translational initiation in response to stress →	+0.172	+0.752	.005	.003	1	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,401 associations by consensus.

Regulation of translation initiation in response to endoplasmic reticulum stress by TM9SF2 expression — URINARY_TRACT

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