TM7SF2

Across TCGA patient cohorts, TM7SF2 RNA expression is significantly associated with the RNA expression of many other genes, with 16,628 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible TM7SF2-associated genes across cancer lineages are RNF208, ZNHIT2, and ERG28. Each is linked with TM7SF2 in more than 29 cancer types. Because this analysis shows association rather than direction, both TM7SF2-to-partner and partner-to-TM7SF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TM7SF2 versus RNF208 in SCLC, with a Pearson correlation of 0.53.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM7SF2→partner) and Y-score (partner→TM7SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	RNF208 →	+1.782	+1.069	<.001	<.001	3	30
DLBC	ZNHIT2 →	+0.950	+1.017	<.001	<.001	3	29
ACC	ERG28 →	+1.426	+1.465	<.001	<.001	3	28
SCLC	TIGD3 →	+1.177	+1.075	<.001	<.001	3	27
DLBC	MFSD3 →	+1.043	+0.939	<.001	<.001	3	27
LAML	CCDC106 →	+1.063	+0.643	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,628 associations by consensus.

TM7SF2 vs RNF208 — SCLC

Explore this scatter interactively →