TM7SF2

Across TCGA pan-cancer cohorts, TM7SF2 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TM7SF2 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher TM7SF2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TM7SF2 expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRC show a favorable association.

LGG, SKCM, and KIRC are the cancer types where TM7SF2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.492	0.294	<.001	52	view →
SKCM	OS	Median	All	0.262	0.502	<.001	50	view →
KIRC	DFS	Quartile	All	0.726	0.350	<.001	34	view →
KIRP	DFS	Tertile	All	0.914	0.778	.006	25	view →
MESO	OS	Median	III,IV	0.451	0.659	.006	12	view →
UCEC	DFS	Median	All	0.872	0.920	.023	12	view →
PCPG	DFS	Median	All	0.863	0.985	.010	12	view →
COAD	DFS	Tertile	All	0.603	0.786	.013	10	view →
ACC	DFS	Tertile	III,IV	0.586	0.099	.026	9	view →
DLBC	DFS	Quartile	All	0.489	1.000	.021	7	view →
SARC	DFS	Quartile	All	0.645	0.480	.013	6	view →
CHOL	DFS	Tertile	II,III,IV	0.124	0.532	.007	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TM7SF2–LGG (DFS)

Open the LGG breakdown →