TM7SF2

Across TCGA patient cohorts, TM7SF2 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM7SF2-associated genes across cancer lineages are Chk2 and 14-3-3_beta. Each is linked with TM7SF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM7SF2-to-partner and partner-to-TM7SF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2 grouped by TM7SF2-low versus TM7SF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM7SF2→partner) and Y-score (partner→TM7SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2 →	-0.246	-2.321	.036	.035	3	1
UCEC	14-3-3_beta →	-0.108	-2.308	.033	.036	2	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Chk2 by TM7SF2 expression — UCEC

Explore this box plot interactively →