TM7SF2

Across TCGA cell cohorts, TM7SF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,870 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TM7SF2-associated GO terms across cancer lineages are Secondary alcohol biosynthetic process, Cholesterol biosynthetic process via lathosterol, and Cholesterol biosynthetic process. Each is linked with TM7SF2 in more than 17 cancer types. Because this analysis shows association rather than direction, both TM7SF2-to-partner and partner-to-TM7SF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Secondary alcohol biosynthetic process grouped by TM7SF2-low versus TM7SF2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TM7SF2→partner) and Y-score (partner→TM7SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Secondary alcohol biosynthetic process →	+0.173	+1.335	<.001	<.001	3	18
BONE	Cholesterol biosynthetic process via lathosterol →	+0.205	+2.137	<.001	<.001	3	18
LUNG_NSCLC_LUAD	Cholesterol biosynthetic process →	+0.173	+1.335	<.001	<.001	3	18
LUNG_SCLC	Sterol biosynthetic process →	+0.154	+1.170	.003	.006	3	16
BONE	Alcohol biosynthetic process →	+0.118	+2.468	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Steroid biosynthetic process →	+0.167	+2.067	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,870 associations by consensus.

Secondary alcohol biosynthetic process by TM7SF2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →