TM7SF2

Across TCGA cell cohorts, TM7SF2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TM7SF2-associated genes across cancer lineages are OR10G4 and CFHR2. Each is linked with TM7SF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM7SF2-to-partner and partner-to-TM7SF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G4 grouped by TM7SF2-low versus TM7SF2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM7SF2→partner) and Y-score (partner→TM7SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR10G4 →	+0.024	+4.930	.004	.008	3	1
LARGE_INTESTINE	CFHR2 →	+0.057	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR10G4 by TM7SF2 expression — SOFT_TISSUE

Explore this box plot interactively →