TM6SF1

Across TCGA patient cohorts, TM6SF1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,150 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TM6SF1-associated genes across cancer lineages are LAIR1, SLCO2B1, and RNASE6. Each is linked with TM6SF1 in more than 6 cancer types. Because this analysis shows association rather than direction, both TM6SF1-to-partner and partner-to-TM6SF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TM6SF1 versus LAIR1 in GBM, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM6SF1→partner) and Y-score (partner→TM6SF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LAIR1 →	+1.288	+0.675	<.001	<.001	3	7
OV	SLCO2B1 →	+1.385	+0.589	<.001	<.001	3	6
HNSC	RNASE6 →	+1.487	+0.692	.003	.002	3	6
OV	CSF1R →	+1.513	+0.650	<.001	<.001	3	6
OV	CST7 →	+2.300	+0.715	<.001	<.001	3	6
OV	VSIG4 →	+1.543	+0.642	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,150 associations by consensus.

TM6SF1 vs LAIR1 — GBM

Explore this scatter interactively →