TM4SF5

Across TCGA pan-cancer cohorts, TM4SF5 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TM4SF5 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TM4SF5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TM4SF5 expression acts as an unfavorable survival marker.

HNSC, COAD, and LIHC are the cancer types where TM4SF5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.132	0.768	<.001	24	view →
COAD	OS	Median	II,III,IV	0.511	0.789	.031	3	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TM4SF5–HNSC (OS)

Open the HNSC breakdown →