TM4SF5

Across TCGA pan-cancer cohorts, TM4SF5 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TM4SF5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where TM4SF5 RNA is repressed in tumor relative to normal tissue. In most cancer types TM4SF5 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and KIRC are the cancer types where TM4SF5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TM4SF5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	All	−1.938	<.001	10	view →
KICH	All	II,III,IV	−3.371	<.001	8	view →
KIRC	Male	II,III,IV	+2.287	<.001	8	view →
CHOL	All	All	−2.802	<.001	5	view →
COAD	Male	III,IV	+1.557	.011	4	view →
LIHC	Male	All	+0.931	<.001	4	view →
BLCA	All	III,IV	+0.102	.007	4	view →
LUAD	All	All	+0.538	.006	3	view →
BRCA	Female	II,III,IV	+0.050	.037	2	view →
READ	All	II,III,IV	−1.115	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TM4SF5–KIRP

Open the KIRP breakdown →