TM4SF5

Across TCGA patient cohorts, TM4SF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,963 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible TM4SF5-associated GO terms across cancer lineages are Polyamine metabolic process, Fatty-acyl-CoA metabolic process, and Thioester metabolic process. Each is linked with TM4SF5 in more than 11 cancer types. Because this analysis shows association rather than direction, both TM4SF5-to-partner and partner-to-TM4SF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Polyamine metabolic process grouped by TM4SF5-low versus TM4SF5-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF5→partner) and Y-score (partner→TM4SF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Polyamine metabolic process →	+0.070	+2.884	<.001	<.001	3	12
ESCA	Fatty-acyl-CoA metabolic process →	+0.056	+2.706	<.001	<.001	3	11
ESCA	Thioester metabolic process →	+0.037	+2.055	<.001	<.001	3	11
TGCT	Galactose catabolic process →	+0.062	+1.277	<.001	<.001	3	11
ESCA	Myelin maintenance →	+0.091	+2.844	<.001	<.001	3	10
ESCA	Putrescine metabolic process →	+0.131	+3.762	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,963 associations by consensus.

Polyamine metabolic process by TM4SF5 expression — ESCA

Explore this box plot interactively →