TM4SF5

Across TCGA patient cohorts, TM4SF5 mutation is significantly associated with the RNA expression of many other genes, with 1,155 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM4SF5-associated genes across cancer lineages are ZNF367, HNRNPA1P19, and MIR4695. Each is linked with TM4SF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF5-to-partner and partner-to-TM4SF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF367 grouped by TM4SF5-low versus TM4SF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF5→partner) and Y-score (partner→TM4SF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF367 →	+0.803	+3.343	.001	.005	3	2
COAD	HNRNPA1P19 →	+0.285	+3.364	<.001	.003	3	2
CESC	MIR4695 →	+0.369	+5.837	<.001	.001	3	2
LUSC	CYP4F36P →	+0.298	+5.563	<.001	<.001	3	2
UCEC	AKAP17A →	+0.414	+2.786	.005	.002	3	2
SKCM	IPPKP1 →	+0.030	+3.224	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,155 associations by consensus.

ZNF367 by TM4SF5 expression — UCEC

Explore this box plot interactively →