TM4SF5

Across TCGA patient cohorts, TM4SF5 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM4SF5-associated genes across cancer lineages are JNK2, XBP1, and Caspase-7-cleavedD198. Each is linked with TM4SF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF5-to-partner and partner-to-TM4SF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by TM4SF5-low versus TM4SF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF5→partner) and Y-score (partner→TM4SF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.263	+3.321	.011	.010	3	1
UCEC	XBP1 →	-0.199	-3.000	.007	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+1.034	+3.321	<.001	.010	3	1
UCEC	14-3-3_beta →	-0.162	-3.308	.002	.010	2	1
UCEC	Tuberin →	+0.318	+2.817	.024	.036	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

JNK2 by TM4SF5 expression — UCEC

Explore this box plot interactively →