TM4SF5

Across TCGA cell cohorts, TM4SF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,520 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TM4SF5-associated GO terms across cancer lineages are Renal D-glucose absorption, Cellular response to rapamycin, and Response to rapamycin. Each is linked with TM4SF5 in more than 5 cancer types. Because this analysis shows association rather than direction, both TM4SF5-to-partner and partner-to-TM4SF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Renal D-glucose absorption grouped by TM4SF5-low versus TM4SF5-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF5→partner) and Y-score (partner→TM4SF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Renal D-glucose absorption →	+1.741	+4.483	<.001	<.001	3	6
STOMACH	Cellular response to rapamycin →	-0.175	-2.718	<.001	<.001	3	6
STOMACH	Response to rapamycin →	-0.147	-2.546	<.001	<.001	3	5
LIVER	Brush border assembly →	+1.584	+4.066	<.001	<.001	3	5
LIVER	Negative regulation of T cell mediated cytotoxicity →	+1.825	+3.764	<.001	<.001	3	5
LARGE_INTESTINE	Follicular B cell differentiation →	+1.422	+2.435	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,520 associations by consensus.

Renal D-glucose absorption by TM4SF5 expression — LIVER

Explore this box plot interactively →