TM4SF5

Across TCGA cell cohorts, TM4SF5 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TM4SF5-associated genes across cancer lineages are TNP1, CLPS, and OR2V2. Each is linked with TM4SF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF5-to-partner and partner-to-TM4SF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNP1 grouped by TM4SF5-low versus TM4SF5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF5→partner) and Y-score (partner→TM4SF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNP1 →	+0.160	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CLPS →	+0.751	+4.273	<.001	.006	3	1
LARGE_INTESTINE	OR2V2 →	+0.020	+4.095	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR52E2 →	+0.341	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRAMEF9 →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.207	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

TNP1 by TM4SF5 expression — LARGE_INTESTINE

Explore this box plot interactively →