TM4SF4

Across TCGA patient cohorts, TM4SF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,067 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible TM4SF4-associated GO terms across cancer lineages are Regulation of microvillus assembly, Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, and Maintenance of blood-brain barrier. Each is linked with TM4SF4 in more than 12 cancer types. Because this analysis shows association rather than direction, both TM4SF4-to-partner and partner-to-TM4SF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of microvillus assembly grouped by TM4SF4-low versus TM4SF4-high in THYM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF4→partner) and Y-score (partner→TM4SF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	Regulation of microvillus assembly →	+0.072	+0.136	<.001	<.001	3	13
ESCA	Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules →	+0.147	+2.913	<.001	<.001	3	12
ESCA	Maintenance of blood-brain barrier →	+0.077	+2.186	<.001	<.001	3	12
ESCA	Tight junction organization →	+0.064	+2.365	<.001	<.001	3	11
ESCA	Apical junction assembly →	+0.076	+2.714	<.001	<.001	3	11
ESCA	Multivesicular body organization →	+0.051	+1.447	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,067 associations by consensus.

Regulation of microvillus assembly by TM4SF4 expression — THYM

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