TM4SF4

Across TCGA patient cohorts, TM4SF4 protein abundance is significantly associated with the RNA expression of many other genes, with 296 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible TM4SF4-associated genes across cancer lineages are HSCB, ISM1, and FAM189A1. Each is linked with TM4SF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF4-to-partner and partner-to-TM4SF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TM4SF4 versus HSCB in PDAC, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF4→partner) and Y-score (partner→TM4SF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HSCB →	-0.223	-0.732	.001	.002	3	1
PDAC	ISM1 →	+0.693	+0.915	.002	<.001	3	1
PDAC	FAM189A1 →	+0.387	+0.706	.003	.003	3	1
PDAC	STMN2 →	+1.101	+0.820	.005	.002	3	1
PDAC	ERI1 →	-0.287	-0.842	.004	.004	3	1
PDAC	COMP →	+1.094	+0.874	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 296 associations by consensus.

TM4SF4 vs HSCB — PDAC

Explore this scatter interactively →