TM4SF4

Across TCGA patient cohorts, TM4SF4 mutation is significantly associated with the RNA expression of many other genes, with 148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM4SF4-associated genes across cancer lineages are RNU6-340P, RNU6-1068P, and RNU6-712P. Each is linked with TM4SF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF4-to-partner and partner-to-TM4SF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-340P grouped by TM4SF4-low versus TM4SF4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF4→partner) and Y-score (partner→TM4SF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-340P →	+0.341	+5.788	<.001	.003	3	2
COAD	RNU6-1068P →	+0.493	+5.602	<.001	.004	3	2
SKCM	RNU6-712P →	+0.196	+5.421	<.001	.001	3	2
LUSC	CTHRC1P1 →	+0.126	+5.211	<.001	.007	3	2
SKCM	CICP15 →	+0.010	+3.292	<.001	.006	3	2
OV	MIR6777 →	+0.692	+7.197	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 148 associations by consensus.

RNU6-340P by TM4SF4 expression — BLCA

Explore this box plot interactively →