TM4SF4

Across TCGA patient cohorts, TM4SF4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM4SF4-associated genes across cancer lineages are 14-3-3_beta, Heregulin, and ACVRL1. Each is linked with TM4SF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF4-to-partner and partner-to-TM4SF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TM4SF4-low versus TM4SF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF4→partner) and Y-score (partner→TM4SF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.117	-3.156	.034	.020	3	1
UCEC	Heregulin →	-0.177	-3.169	.009	.020	3	1
UCEC	ACVRL1 →	+0.173	+3.019	.020	.019	3	1
UCEC	PKC-delta_pS664 →	+0.198	+2.817	.002	.036	3	1
UCEC	STAT5a →	+0.454	+3.169	.038	.020	3	1
UCEC	Chk2 →	-0.420	-3.169	.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

14-3-3_beta by TM4SF4 expression — UCEC

Explore this box plot interactively →