TM4SF19-AS1

Across TCGA pan-cancer cohorts, TM4SF19-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TM4SF19-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TM4SF19-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TM4SF19-AS1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KIRP, and LIHC are the cancer types where TM4SF19-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TM4SF19-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.990	<.001	12	view →
KIRP	All	II,III,IV	+0.438	<.001	11	view →
LIHC	Male	II,III,IV	+0.369	<.001	8	view →
COAD	Male	III,IV	+0.305	<.001	8	view →
LUSC	Male	All	+1.060	<.001	7	view →
KIRC	Male	All	+0.164	.003	7	view →
BLCA	All	All	+0.563	.017	6	view →
KICH	Female	All	−0.533	<.001	3	view →
STAD	All	II,III,IV	+0.415	.044	3	view →
CHOL	Male	All	+0.426	<.001	2	view →
UCEC	All	All	−0.360	.005	2	view →
PRAD	All	All	+0.114	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TM4SF19-AS1–HNSC

Open the HNSC breakdown →