TLX3

Across TCGA cell cohorts, TLX3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TLX3-associated genes across cancer lineages are SERPINA7, OR8D4, and TMEM207. Each is linked with TLX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLX3-to-partner and partner-to-TLX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA7 grouped by TLX3-low versus TLX3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLX3→partner) and Y-score (partner→TLX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SERPINA7 →	+0.012	+4.930	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR8D4 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	TMEM207 →	+0.108	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10C1 →	+0.066	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR12D1 →	+0.042	+4.887	<.001	.009	3	1
BLOOD_Leukemia	PRMT8 →	+0.573	+4.409	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SERPINA7 by TLX3 expression — SOFT_TISSUE

Explore this box plot interactively →