TLX1NB

Across TCGA patient cohorts, TLX1NB mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLX1NB-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and GAPDH. Each is linked with TLX1NB in more than 1 cancer types. Because this analysis shows association rather than direction, both TLX1NB-to-partner and partner-to-TLX1NB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TLX1NB-low versus TLX1NB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLX1NB→partner) and Y-score (partner→TLX1NB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.338	-3.459	.007	.005	3	1
UCEC	FoxM1 →	+0.356	+3.459	.006	.005	3	1
UCEC	GAPDH →	+0.577	+2.999	.032	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.281	-3.446	<.001	.005	3	1
UCEC	Ku80 →	+0.306	+2.335	.010	.020	3	1
UCEC	Notch1 →	+0.193	+3.459	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

EGFR_pY1068 by TLX1NB expression — UCEC

Explore this box plot interactively →