TLX1NB

Across TCGA pan-cancer cohorts, TLX1NB RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated TLX1NB data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TLX1NB RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TLX1NB expression acts as an unfavorable survival marker, although some lineages such as HNSC and LGG show a favorable association.

HNSC, DLBC, and ACC are the cancer types where TLX1NB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.780	0.561	.002	68	view →
DLBC	DFS	Tertile	All	0.338	0.795	.010	67	view →
ACC	OS	Tertile	All	0.666	0.893	.001	48	view →
KIRP	DFS	Tertile	IV	0.088	0.502	<.001	45	view →
LGG	DFS	Median	All	0.801	0.667	<.001	39	view →
LIHC	DFS	Median	All	0.445	0.603	<.001	29	view →
COAD	DFS	Quartile	All	0.389	0.674	.002	25	view →
UCS	OS	Median	IV	0.302	0.817	.002	24	view →
READ	OS	Median	II,III,IV	0.812	0.303	<.001	21	view →
THYM	DFS	Median	II,III,IV	0.946	0.506	.004	15	view →
CESC	OS	Tertile	II,III,IV	0.863	0.698	.030	8	view →
STAD	DFS	Median	II,III,IV	0.304	0.461	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

TLX1NB–HNSC (DFS)

Open the HNSC breakdown →