TLR9

Across TCGA patient cohorts, TLR9 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,092 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible TLR9-associated GO terms across cancer lineages are Glycerophospholipid metabolic process, Epigenetic regulation of gene expression, and Obsolete histone methylation. Each is linked with TLR9 in more than 31 cancer types. Because this analysis shows association rather than direction, both TLR9-to-partner and partner-to-TLR9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycerophospholipid metabolic process grouped by TLR9-low versus TLR9-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR9→partner) and Y-score (partner→TLR9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Glycerophospholipid metabolic process →	+0.040	+0.048	<.001	<.001	3	32
SCLC	Epigenetic regulation of gene expression →	+0.078	+0.768	<.001	.001	3	32
SCLC	Obsolete histone methylation →	+0.142	+0.601	<.001	.007	2	32
STAD	Nuclear-transcribed mRNA catabolic process →	+0.062	+0.066	<.001	<.001	3	31
SCLC	Autophagosome maturation →	+0.059	+0.667	.002	<.001	3	30
STAD	Vesicle-mediated transport to the plasma membrane →	+0.055	+0.055	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,092 associations by consensus.

Glycerophospholipid metabolic process by TLR9 expression — STAD

Explore this box plot interactively →